(Ebook) Evolutionary Protein Design 1st Edition by Frances H Arnold ISBN 9780120342556 0120342553

(Ebook) Evolutionary Protein Design 1st Edition by Frances H Arnold ISBN 9780120342556 0120342553

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ISBN 10: 0120342553
ISBN 13: 9780120342556
Author: Frances H Arnold

(Ebook) Evolutionary Protein Design 1st Edition Table of contents:

Chapter 1. New Functions from Old Scaffolds: How Nature Reengineers Enzymes for New Functions

I. Introduction

II. Defining Protein Superfamilies

III. The Enolase Superfamily: A Paradigm for Understanding How Nature Evolved Enzymes for New Functi

IV. Studies of Other Superfamilies and Fold Classes

V. Conclusions

VI. References

Chapter 2. Evolution of Protein Functon by Domain Swapping

I. Introduction

II. Terminology

III. Evolution of Proteins in Nature by Domain Swapping

IV. Domain Swapping for Protein Engineering

V. Methodologies

VI. Perspective

References

Chapter 3. Rational Evolutionary Design: The Theory of In Vitro Protein Evolution

I. Introduction

II. Sequence Space and Fitness Landscapes

III. Modeling Directed Evolution

IV. Rational Evolutionary Design

V. Summary and Conclusions

References

Chapter 4. Temperature Adaptation of Enzymes: Lessons from Laboratory Evolution

I. Introduction

II. Influence of Temperature on Enzymes

III. Studies of Natural Extremophilic Enzymes

IV. Directed Evolution

V. Stability, Flexibility, and Catalytic Activity

VI. Why Are Proteins Marginally Stable?

VII. Why Are Thermophilic Enzymes Poorly Active at Low Temperature?

VIII. Conclusions

References

Chapter 5. Structural Analysis of Affinity Matured Antibodies and Laboratory-Evolved Enzymes

I. Introduction

II. Structural Studies of Antibody Affnity Maturation

III. Structural Studies of Enzyme Directed Evolution

IV. Conclusions

References

Chapter 6. Molecular Breeding: The Natural Approach to Protein Design

I. Introduction

II. The Need for Better Proteins

III. Strategies for Optimizing Proteins

IV. Screening Is Key

V. Beyond Proteins

VI. Concluding Remarks

References

Chapter 7. Analysis of Large Libraries of Protein Mutants Using Flow Cytometry

I. Introduction

II. Library Screening Technologies

III. Cell Surface Display Technologies

IV. Library Screening by Flow Cytometry

V. Concluding Remarks

References

Chapter 8. From Catalytic Asymmetric Synthesis to the Transcriptional Regulation of Genes: In Vivo a

I. Introduction and Scope of Review

II. Selecting and Evolving Therapeutic Human Antibodies

III. Directing Evolution at the Level of Chemical Mechanism: Aldolase Antibodies and Asymmetric Cata

IV. Multiple Hapten Selection: Refining the Active Site of a Catalytic Antibody by In Vitro Selectio

V. Selection and Evolution of Novel DNA-Binding Proteins: From Principles to Applications

References

Chapter 9. In Vitro Selection and Evolution of Proteins

I. Introduction

II. The Key to In Vitro Protein Evolution: Cell-Free Translation

III. In Vitro Selection Strategies

IV. Applications of Ribosome Display

V. Perspectives of Directed In Vitro Evolution

References

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