Most ebook files are in PDF format, so you can easily read them using various software such as Foxit Reader or directly on the Google Chrome browser.
Some ebook files are released by publishers in other formats such as .awz, .mobi, .epub, .fb2, etc. You may need to install specific software to read these formats on mobile/PC, such as Calibre.
Please read the tutorial at this link. https://ebooknice.com/page/post?id=faq
We offer FREE conversion to the popular formats you request; however, this may take some time. Therefore, right after payment, please email us, and we will try to provide the service as quickly as possible.
For some exceptional file formats or broken links (if any), please refrain from opening any disputes. Instead, email us first, and we will try to assist within a maximum of 6 hours.
EbookNice Team
Status:
Available4.4
23 reviewsDramatic drop in reproductive hormone, especially estrogen level, from pregnancy to postpartum period is known to contribute topostpartum depression (PPD), but the underlying mechanism and the role of the estrogen receptors (ERs) in this process were unclear.Here, we used an estrogen-withdrawal-induced PPD model following hormone simulated pregnancy (HSP) in female Sprague-Dawleyrats to induce depressive-like behaviors. After estrogen withdrawal, we observe an up-regulation of astrocyte-specific potassiumchannel (Kir4.1) in the brain’s anti-reward center lateral habenula (LHb), along with enhanced bursting and excitability of LHb neurons.1234567890();,:Among all 3 subtypes of ERs in the LHb, only ERβ shows an HSP-correlated expression temporal dynamics. Systemic administration ofselective ERβ agonist, but not agonists of other subtypes of ERs, inhibits neuronal bursting activities and blocks up-regulation of Kir4.1 inthe LHb, as well as decreases estrogen-withdrawal-induced depressive-like behavior. Importantly, intra-LHb injection of ERβ agonist issufficient to rescue depressive-like behaviors induced by estrogen withdrawal. Conversely, local knock-down of ERβ in the LHbsuppresses the antidepressant-like effect of estrogen. Our results reveal a critical role of LHb in the pathogenesis of hormone-sensitivePPD and ERβ as a critical mediator of estrogen’s antidepressant effects on PPD.Molecular Psychiatry;