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0 reviewsAffiliations:1 Department of Radiology, Taihe Hospital, Hubei University of Medicine, Shiyan, China2 Mental Health Center, Taihe Hospital, Hubei University of Medicine, Shiyan, China3 Huaxi Magnetic Resonance Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China4 Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA5 The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China6 The Turner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging, Monash University, Clayton, Australia# Kun Qin and Chunqi Ai contributed equally to this work.*Corresponding Author: Prof. Wen Chen (Email: [email protected]), Department of Radiology, Taihe Hospital, Hubei University of Medicine, No.32 Renmin South Road, Maojian District, 442000, Shiyan, Hubei, China.Dr. Kun Qin (Email: [email protected]), Department of Radiology, Taihe Hospital, Hubei University of Medicine, No.32 Renmin South Road, Maojian District, 442000, Shiyan, Hubei, China. Running title: Edge-centric connectome dysfunction in depressionKeywords: Depression; Magnetic resonance imaging; Edge-centric; Reward circuit; Gene expression; Neurotransmitter