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0 reviewsSUMMARYDe novo design of antimicrobial peptides (AMPs) is challenging due to the vast combinatorial space and unknown mechanisms. We propose EBAMP, a generative-discriminative framework for de novo broad-spectrum AMP design targeting bacteria and fungi. EBAMP combines a Transformer-based generative modelwith advanced feature-based screening to explore peptide space and select multiobjective candidates.Experimental testing of 256 designed sequences shows that 96 (37.5%) display bactericidal ability. Thetop 10 sequences exhibit low cytotoxicity, low hemolysis, and strong antibacterial effect (2 μg/mL) againstmultidrug-resistant bacteria and fungi. In vivo mouse full-thickness wound infection model demonstratesinhibitory effects against Acinetobacter baumannii (bacterium) and Candida auris (fungus), with therapeuticefficiency comparable to antibiotics but lower resistance propensity. Alanine substitution analysis and molecular dynamics reveal functionally critical positions. EBAMP showcases large generative models for broadspectrum AMP discovery and addresses antibiotic resistance.
