(Ebook) Drug-Drug Interactions, Second Edition (Drugs and the Pharmaceutical Sciences) by A. David Rodrigues ISBN 9780849375934, 9780849375941, 0849375932, 0849375940

(Ebook) Drug-Drug Interactions, Second Edition (Drugs and the Pharmaceutical Sciences) by A. David Rodrigues ISBN 9780849375934, 9780849375941, 0849375932, 0849375940

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives. Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on: key interplay between transporters and enzymes in drug metabolism and drug interactions the integral role of pharmacogenetics in metabolism-based drug-drug interactions in vivo – in vitro correlations (reversible, mechanism-based inhibition, induction) in silico approaches enabling structure-activity and structure-function studies high-throughput screening and GLP methods for evaluating drug interactions in vitro the use of transgenic animal models to evaluate drug interactions Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.