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35 reviewsAbstract— Objective: This study investigated the attenuation of structures, such as bone and soft tissue, and spatial precision on somatosensation in healthy subjects (n = 18) and subjects with the order of millimeters. FUS has been used to modulate neural carpal tunnel syndrome (CTS) (n = 6) via displacement-guided activity in both central [1]–[10] and peripheral [11]–[15]median nerve focused ultrasound (FUS). Somatosensory evoked nervous systems. When targeted to peripheral nerves, FUS can potentials (SSEPs), pain, stiffness, and numbness were used as induce motor movement [12], [14], elicit sensation [11], and markers of sensation. Methods: Electroencephalography (EEG) even reduce pain in both healthy [16]–[18] and neuropathic was used to evaluate changes in electrically-induced SSEPs when paired with FUS. Subjects underwent 1,000 (healthy population) [18]–[23] humans. Specifically, previous studies from our or 500 (CTS population) surface electrical pulses at a maximum group have demonstrated reductions of verbal pain ratings from rate of 1 Hz to the median nerve to invoke a thumb twitch. Half of median nerve sonication in healthy subjects subjected to these pulses were paired with 5 ms of upstream median nervethermal pain [17], [18] and, separately, reductions in sonication from a 1.1 MHz transducer at 1.8 or 2.9 MPa derated mechanically elicited pain in neuropathic patients from peak-positive pressure. Results: On-nerve sonication reduced the sonication of their injured nerves [18]. amplitude of SSEPs at both pressures. Reductions in beta and lowgamma frequency power occurred in healthy subjects and To design and characterize effective neuromodulation for increases in alpha power occurred in CTS subjects. CTS subjectspain treatment, the ability of peripheral FUS to modulate who received on-nerve sonication reported an average pain sensory transduction from the periphery to the centra