(Ebook) Computational Methods for Processing and Analysis of Biological Pathways by Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos (auth.) ISBN 9783319538679, 9783319538686, 3319538675, 3319538683

(Ebook) Computational Methods for Processing and Analysis of Biological Pathways by Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos (auth.) ISBN 9783319538679, 9783319538686, 3319538675, 3319538683

This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways.