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Status:
Available4.6
29 reviews
ISBN 10: 1119536650
ISBN 13: 9781119536628
Author: Julian PT Higgins, James Thomas, Jacqueline Chandler
The second edition of The Cochrane Handbook for Systematic Reviews of Interventions contains essential guidance for preparing and maintaining Cochrane Reviews of the effects of health interventions. Designed to be an accessible resource, the Handbook will also be of interest to anyone undertaking systematic reviews of interventions outside Cochrane, and many of the principles and methods presented are appropriate for systematic reviews addressing research questions other than effects of interventions.
This fully updated edition contains extensive new material on systematic review methods addressing a wide-range of topics including network meta-analysis, equity, complex interventions, narrative synthesis, and automation. Also new to this edition, integrated throughout the Handbook, is the set of standards Cochrane expects its reviews to meet.
Written for review authors, editors, trainers and others with an interest in Cochrane Reviews, the second edition of The Cochrane Handbook for Systematic Reviews of Interventions continues to offer an invaluable resource for understanding the role of systematic reviews, critically appraising health research studies and conducting reviews.
Part One: Core methods
1 Starting a review
1.1 Why do a systematic review?
1.2 What is the review question?
...
2 Determining the scope of the review and the questions it will address
2.1 Rationale for well‐formulated questions
2.2 Aims of reviews of interventions
...
3 Defining the criteria for including studies and how they will be grouped for the synthesis
3.1 Introduction
3.2 Articulating the review and comparison PICO
...
4 Searching for and selecting studies
4.1 Introduction
4.2 General issues
...
5 Collecting data
5.1 Introduction
5.2 Sources of data
...
6 Choosing effect measures and computing estimates of effect
6.1 Types of data and effect measures
6.2 Study designs and identifying the unit of analysis
...
7 Considering bias and conflicts of interest among the included studies
7.1 Introduction
7.2 Empirical evidence of bias
...
8 Assessing risk of bias in a randomized trial
8.1 Introduction
8.2 Overview of RoB 2
...
9 Summarizing study characteristics and preparing for synthesis
9.1 Introduction
9.2 A general framework for synthesis
...
10 Analysing data and undertaking meta‐analyses
10.1 Do not start here!
10.2 Introduction to meta‐analysis
...
11 Undertaking network meta‐analyses
11.1 What is network meta‐analysis?
11.2 Important concepts
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12 Synthesizing and presenting findings using other methods
12.1 Why a meta‐analysis of effect estimates may not be possible
12.2 Statistical synthesis when meta‐analysis of effect estimates is not possible
...
13 Assessing risk of bias due to missing results in a synthesis
13.1 Introduction
13.2 Minimizing risk of bias due to missing results
...
14 Completing ‘Summary of findings’ tables and grading the certainty of the evidence
14.1 ‘Summary of findings’ tables
14.2 Assessing the certainty or quality of a body of evidence
...
15 Interpreting results and drawing conclusions
15.1 Introduction
15.2 Issues of indirectness and applicability
...
Part Two: Specific perspectives in reviews
16 Equity and specific populations
16.1 Introduction to equity in systematic reviews
16.2 Formulation of the review
...
17 Intervention complexity
17.1 Introduction
17.2 Formulation of the review
...
18 Patient‐reported outcomes
18.1 Introduction to patient‐reported outcomes
18.2 Formulation of the review
...
19 Adverse effects
19.1 Introduction to issues in addressing adverse effects
19.2 Formulation of the review
...
20 Economic evidence
20.1 Introduction
20.2 Formulation of the review
...
21 Qualitative evidence
21.1 Introduction
21.2 Designs for synthesizing and integrating qualitative evidence with intervention reviews
...
Part Three: Further topics
22 Prospective approaches to accumulating evidence
22.1 Introduction
22.2 Evidence surveillance: active monitoring of the accumulating evidence
...
23 Including variants on randomized trials
23.1 Cluster‐randomized trials
23.2 Crossover trials
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24 Including non‐randomized studies on intervention effects
24.1 Introduction
24.2 Developing criteria for including non‐randomized studies of interventions
...
25 Assessing risk of bias in a non‐randomized study
25.1 Introduction
25.2 Biases in non‐randomized studies
...
26 Individual participant data
26.1 Introduction
26.2 Collecting IPD
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Tags: Julian PT Higgins, James Thomas, Jacqueline Chandler, Cochrane, Systematic
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