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ISBN 13: 9781119542384
Author: Siraj A Misbah, Gavin P Spickett, Virgil ASH Dalm
The Essentials are an international, best-selling series of textbooks, all of which are designed to support lecture series or themes on core topics within the health sciences. See www.wiley.com for further details.
The fully updated new edition of the classic textbook, introducing the pathophysiology and management of immunological disorders
Chapel and Haeney’s Essentials of Clinical Immunology contains the knowledge necessary to understand the diagnosis and treatment of immunological disorders. With easy-to-read text and a wealth of colour clinical images and diagrams, this well-regarded textbook introduces complex concepts using effective pedagogical tools such as bulleted lists, key point boxes, real-life case studies, practical examples, figures and tables, chapter introductions, and keywords in bold integrated in each chapter.
Fully updated throughout, the seventh edition provides up-to-date coverage of the clinical relevance that immunology has in medicine. These new and revised sections examine current research trends, the implementation of automation in laboratories, the emerging field of neuro-psychiatric disorders such as NMDA receptor encephalitis and more. This edition includes new end-of-chapter summaries, updated clinical information, additional real-life case histories illustrating key concepts, and linking immunological testing to diseases. The new edition also includes:
Chapel and Haeney’s Essentials of Clinical Immunology is an ideal resource for clinical medical students, junior doctors, medical residents and other medical professionals who are looking to expand or refresh their knowledge in clinical immunology, as well as being an excellent introductory textbook for undergraduate courses in the subject.
CHAPTER 1: Basic Components: Structure and Function
1.2 Key molecules
1.3 Functional basis of innate responses
1.4 Functional basis of the adaptive immune responses
1.5 Physiological outcomes of immune responses
1.6 Tissue damage caused by the immune system
1.7 Organization of the immune system: an overview
1.8 Conclusions
CHAPTER 2: Infection
2.2 Normal resistance to infection
2.3 Viral infection
2.4 Bacterial infection
2.5 Mycobacterial infection
2.6 Fungal infection
2.7 Parasitic infection
CHAPTER 3: Immunodeficiency
3.2 Primary immune deficiencies
3.3 Primary antibody deficiencies
3.4 Combined primary T‐ and B‐cell immunodeficiencies
3.5 Primary defects in non‐specific immunity
3.6 Secondary immunodeficiency
CHAPTER 4: Anaphylaxis and Allergy
4.2 Immediate (type I) hypersensitivity
4.3 Atopy
4.4 Anaphylaxis
4.5 Allergic conjunctivitis
4.6 Respiratory allergy
4.7 Food allergy and intolerance
4.8 Skin disease and allergy
CHAPTER 5: Autoimmunity
5.2 Patterns of autoimmune disease
5.3 Who gets autoimmune disease?
5.4 What prevents autoimmunity?
5.5 How does tolerance break down?
5.6 What triggers autoimmunity?
5.7 Mechanisms of tissue damage
5.8 Treatment of autoimmune disease
CHAPTER 6: Lymphoproliferative Disorders
6.2 Biology of malignant transformation in haematopoietic cells
6.3 Leukaemia
6.4 Lymphomas
6.5 Plasma cell dyscrasias
CHAPTER 7: Immune Manipulation
7.2 Immunosuppression
7.3 Immunization against infection
7.4 Immune potentiation other than vaccines
CHAPTER 8: Transplantation
8.2 Histocompatibility genetics in humans
8.3 Renal transplantation
8.4 Other types of transplantation
8.5 Haematopoietic stem cell transplantation
CHAPTER 9: Kidney Diseases
9.2 Clinical syndromes
9.3 Classifications of glomerulonephritis
9.4 Asymptomatic haematuria
9.5 Acute glomerulonephritis
9.6 Chronic glomerulonephritis
9.7 Rapidly progressive glomerulonephritis
9.8 Nephrotic syndrome
9.9 Tubulointerstitial nephropathy
9.10 Chronic renal failure
9.11 Recurrent glomerulonephritis in transplanted kidneys
CHAPTER 10: Joints and Muscles
10.2 Patterns of joint disease
10.3 Arthritis and infection
10.4 Rheumatoid arthritis
10.5 Seronegative spondyloarthritis
10.6 Chronic arthritis in children
10.7 Systemic lupus erythematosus
10.8 Other ‘connective tissue’ diseases
10.9 Systemic vasculitis
10.10 Inflammatory muscle disease or myositis
10.11 Hereditary periodic fevers
CHAPTER 11: Skin Diseases
11.2 Infections and the skin
11.3 T cell–mediated skin disease
11.4 Autoimmune skin disease
11.5 Systemic diseases with skin involvement
CHAPTER 12: Eye Diseases
12.2 Conjunctivitis
12.3 Keratitis
12.4 Scleritis
12.5 Uveitis
CHAPTER 13: Chest Diseases
13.2 Respiratory infections
13.3 Granulomatous diseases
13.4 Interstitial lung disease
13.5 Connective tissue disease and the lung
13.6 Pulmonary vasculitis
13.7 Cardiac disease
13.8 Coronary artery disease
13.9 Diseases of the great vessels
CHAPTER 14: Gastrointestinal and Liver Diseases
14.2 Infection and the gut
14.3 Gastritis
14.4 Food‐induced gastrointestinal disease
14.5 Autoimmune enteropathy
14.6 Inflammatory bowel disease
14.7 Viral hepatitis
14.8 Autoimmune liver diseases
CHAPTER 15: Endocrinology and Diabetes
15.2 Mechanisms of endocrine autoimmunity
15.3 Thyroid disease
15.4 Diabetes mellitus
15.5 Adrenal disease
15.6 Parathyroid disease
15.7 Gonadal disease
15.8 Infertility
15.9 Pituitary disease
15.10 Autoimmune polyendocrine disease
CHAPTER 16: Non‐malignant Haematological Diseases
16.2 Autoimmune haemolytic anaemias
16.3 Immune thrombocytopenia
16.4 Immune neutropenia
16.5 Haematopoietic progenitor cells
16.6 Immune disorders of coagulation
16.7 Blood transfusion
CHAPTER 17: Neuroimmunology
17.2 Infections
17.3 Demyelinating diseases of the central nervous system
17.4 Autoimmune diseases of the neuromuscular junction
17.5 Immune‐mediated neuropathies
17.6 Paraneoplastic syndromes
17.7 Cerebral systemic lupus erythematosus
17.8 Autoimmune encephalitis
CHAPTER 18: Immunological Diseases in Pregnancy
18.2 Pregnancy and maternal infection
18.3 Protection of the fetus and neonate against infection
18.4 Disorders of pregnancy
18.5 Clinical relevance of antibodies to reproductive components
CHAPTER 19: Techniques in Clinical Immunology
19.2 Investigation of immunoglobulins
19.3 Investigation of complement and immune‐complex disorders
19.4 Antibodies to microbial antigens
19.5 Detection of autoantibodies
19.6 Tests for allergy and hypersensitivity
19.7 Assessment of lymphocytes
19.8 Assessment of neutrophils and monocytes
19.9 Recombinant DNA technology in clinical immunology
19.10 Histocompatibility testing
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Tags: Siraj A Misbah, Gavin P Spickett, Virgil ASH Dalm, Chapel, Clinical Immunology
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