Most ebook files are in PDF format, so you can easily read them using various software such as Foxit Reader or directly on the Google Chrome browser.
Some ebook files are released by publishers in other formats such as .awz, .mobi, .epub, .fb2, etc. You may need to install specific software to read these formats on mobile/PC, such as Calibre.
Please read the tutorial at this link. https://ebooknice.com/page/post?id=faq
We offer FREE conversion to the popular formats you request; however, this may take some time. Therefore, right after payment, please email us, and we will try to provide the service as quickly as possible.
For some exceptional file formats or broken links (if any), please refrain from opening any disputes. Instead, email us first, and we will try to assist within a maximum of 6 hours.
EbookNice Team
Status:
Available4.7
5 reviews
ISBN 10: 0470085851
ISBN 13: 9780470085851
Author: Jonathan Pevsner
The bestselling introduction to bioinformatics and functional genomics—now in an updated edition
Widely received in its previous edition, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded Second Edition, it continues to be the go-to source for students and professionals involved in biomedical research.
This edition provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:
Several fundamentally important proteins, such as globins, histones, insulin, and albumins, are included to better show how to apply bioinformatics tools to basic biological questions.
Descriptions of genome sequencing projects spanning the tree of life.
A stronger focus on how bioinformatics tools are used to understand human disease.
The book is complemented by lavish illustrations and more than 500 figures and tables—fifty of which are entirely new to this edition. Each chapter includes a Problem Set, Pitfalls, Boxes explaining key techniques and mathematics/statistics principles, Summary, Recommended Reading, and a list of freely available software. Readers may visit a related Web page for supplemental information at www.wiley.com/go/pevsnerbioinformatics.
Bioinformatics and Functional Genomics, Second Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.
Part I: Analyzing DNA, RNA, and Protein Sequences in Databases
1: Introduction
ORGANIZATION OF THE BOOK
BIOINFORMATICS: THE BIG PICTURE
A CONSISTENT EXAMPLE: HEMOGLOBIN
ORGANIZATION OF THE CHAPTERS
A TEXTBOOK FOR COURSES ON BIOINFORMATICS AND GENOMICS
KEY BIOINFORMATICS WEBSITES
SUGGESTED READING
REFERENCES
2: Access to Sequence Data and Literature Information
INTRODUCTION TO BIOLOGICAL DATABASES
GENBANK: DATABASE OF MOST KNOWN NUCLEOTIDE AND PROTEIN SEQUENCES
NATIONAL CENTER FOR BIOTECHNOLOGY INFORMATION
THE EUROPEAN BIOINFORMATICS INSTITUTE (EBI)
ACCESS TO INFORMATION: ACCESSION NUMBERS TO LABEL AND IDENTIFY SEQUENCES
ACCESS TO INFORMATION VIA ENTREZ GENE AT NCBI
ACCESS TO INFORMATION: PROTEIN DATABASES
ACCESS TO INFORMATION: THE THREE MAIN GENOME BROWSERS
EXAMPLES OF HOW TO ACCESS SEQUENCE DATA
ACCESS TO BIOMEDICAL LITERATURE
PERSPECTIVE
PITFALLS
WEB RESOURCES
DISCUSSION QUESTIONS
PROBLEMS
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
3: Pairwise Sequence Alignment
INTRODUCTION
SCORING MATRICES
ALIGNMENT ALGORITHMS: GLOBAL AND LOCAL
THE STATISTICAL SIGNIFICANCE OF PAIRWISE ALIGNMENTS
PERSPECTIVE
PITFALLS
WEB RESOURCES
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LAB
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
4: Basic Local Alignment Search Tool (BLAST)
INTRODUCTION
BLAST SEARCH STEPS
BLAST ALGORITHM USES LOCAL ALIGNMENT SEARCH STRATEGY
BLAST SEARCH STRATEGIES
PERSPECTIVE
PITFALLS
WEB RESOURCES
DISCUSSION QUESTIONS
COMPUTER LAB/PROBLEMS
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
5: Advanced Database Searching
INTRODUCTION
SPECIALIZED BLAST SITES
FINDING DISTANTLY RELATED PROTEINS: POSITION-SPECIFIC ITERATED BLAST (PSI-BLAST)
PROFILE SEARCHES: HIDDEN MARKOV MODELS
BLAST-LIKE ALIGNMENT TOOLS TO SEARCH GENOMIC DNA RAPIDLY
USING BLAST FOR GENE DISCOVERY
PERSPECTIVE
PITFALLS
WEB RESOURCES
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LAB
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
6: Multiple Sequence Alignment
INTRODUCTION
FIVE MAIN APPROACHES TO MULTIPLE SEQUENCE ALIGNMENT
DATABASES OF MULTIPLE SEQUENCE ALIGNMENTS
MULTIPLE SEQUENCE ALIGNMENTS OF GENOMIC REGIONS
PERSPECTIVE
PITFALLS
WEB RESOURCES
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LAB
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
7: Molecular Phylogeny and Evolution
INTRODUCTION TO MOLECULAR EVOLUTION
MOLECULAR PHYLOGENY: PROPERTIES OF TREES
TYPE OF TREES
FIVE STAGES OF PHYLOGENETIC ANALYSIS
PHYLOGENETIC METHODS
PERSPECTIVE
PITFALLS
WEB RESOURCES
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LAB
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
Part II: Genomewide Analysis of RNA and Protein
8: Bioinformatic Approaches to Ribonucleic Acid (RNA)
INTRODUCTION TO RNA
NONCODING RNA
INTRODUCTION TO MESSENGER RNA
MICROARRAYS: GENOMEWIDE MEASUREMENT OF GENE EXPRESSION
INTERPRETATION OF RNA ANALYSES
PERSPECTIVE
PITFALLS
WEB RESOURCES
DISCUSSION QUESTIONS
PROBLEMS
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
9: Gene Expression: Microarray Data Analysis
INTRODUCTION
MICROARRAY DATA ANALYSIS: PREPROCESSING
MlCROARRAY DATA ANALYSIS: INFERENTIAL STATISTICS
MICROARRAY DATA ANALYSIS: DESCRIPTIVE STATISTICS
FUNCTIONAL ANNOTATION OF MICROARRAY DATA
PERSPECTIVE
PITFALLS
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LAB
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
10: Protein Analysis and Proteomics
INTRODUCTION
TECHNIQUES TO IDENTIFY PROTEINS
FOUR PERSPECTIVES ON PROTEINS
PERSPECTIVE 1. PROTEIN DOMAINS AND MOTIFS: MODULAR NATURE OF PROTEINS
PERSPECTIVE 2. PHYSICAL PROPERTIES OF PROTEINS
INTRODUCTION TO PERSPECTIVES 3 AND 4: GENE ONTOLOGY CONSORTIUM
PERSPECTIVE 3: PROTEIN LOCALIZATION
PERSPECTIVE 4: PROTEIN FUNCTION
PERSPECTIVE
PITFALLS
WEB RESOURCES
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LAB
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
11: Protein Structure
OVERVIEW OF PROTEIN STRUCTURE
PRINCIPLES OF PROTEIN STRUCTURE
THE PROTEIN DATA BANK
PROTEIN STRUCTURE PREDICTION
INTRINSICALLY DISORDERED PROTEINS
PROTEIN STRUCTURE AND DISEASE
PERSPECTIVE
PITFALLS
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LAB
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
12: Functional Genomics
INTRODUCTION TO FUNCTIONAL GENOMICS
EIGHT MODEL ORGANISMS FOR FUNCTIONAL GENOMICS
FUNCTIONAL GENOMICS USING REVERSE GENETICS AND FORWARD GENETICS
FUNCTIONAL GENOMICS AND THE CENTRAL DOGMA
PROTEOMICS APPROACHES TO FUNCTIONAL GENOMICS
PERSPECTIVE
PITFALLS
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LABORATORY
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
Part III: Genome Analysis
13: Completed Genomes
INTRODUCTION
GENOME-SEQUENCING PROJECTS: OVERVIEW
GENOME ANALYSIS PROJECTS
DNA SEQUENCING TECHNOLOGIES
THE PROCESS OF GENOME SEQUENCING
GENOME ANNOTATION: FEATURES OF GENOMIC DNA
PERSPECTIVE
PITFALLS
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LAB
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
14: Completed Genomes: Viruses
INTRODUCTION
BIOINFORMATICS APPROACHES TO PROBLEMS IN VIROLOGY
INFLUENZA VIRUS
HERPESVIRUS: FROM PHYLOGENY TO GENE EXPRESSION
HUMAN IMMUNODEFICIENCY VIRUS
MEASLES VIRUS
PERSPECTIVES
PITFALLS
WEB RESOURCES
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LAB
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
15: Completed Genomes: Bacteria and Archaea
INTRODUCTION
CLASSIFICATION OF BACTERIA AND ARCHAEA
ANALYSIS OF PROKARYOTIC GENOMES
COMPARISON OF PROKARYOTIC GENOMES
PERSPECTIVE
PITFALLS
WEB RESOURCES
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LAB
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
16: The Eukaryotic Chromosome
INTRODUCTION
GENERAL FEATURES OF EUKARYOTIC GENOMES AND CHROMOSOMES
REPETITIVE DNA CONTENT OF EUKARYOTIC CHROMOSOMES
GENE CONTENT OF EUKARYOTIC CHROMOSOMES
REGULATORY REGIONS OF EUKARYOTIC CHROMOSOMES
COMPARISON OF EUKARYOTIC DNA
VARIATION IN CHROMOSOMAL DNA
TECHNIQUES TO MEASURE CHROMOSOMAL CHANGE
PERSPECTIVE
PITFALLS
WEB RESOURCES
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LAB
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
17: Eukaryotic Genomes: Fungi
INTRODUCTION
INTRODUCTION TO BUDDING YEAST SACCHAROMYCES CEREVISIAE
GENE DUPLICATION AND GENOME DUPLICATION OF S. CEREVISIAE
COMPARATIVE ANALYSES OF HEMIASCOMYCETES
ANALYSIS OF FUNGAL GENOMES
PERSPECTIVE
PITFALLS
WEB RESOURCES
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LAB
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
18: Eukaryotic Genomes: From Parasites to Primates
INTRODUCTION
PROTOZOANS AT THE BASE OF THE TREE LACKING MITOCHONDRIA
GENOMES OF UNICELLULAR PATHOGENS: TRYPANOSOMES AND LEISHMANIA
THE CHROMALVEOLATES
PLANT GENOMES
SLIME AND FRUITING BODIES AT THE FEET OF METAZOANS
METAZOANS
PERSPECTIVE
PITFALLS
WEB RESOURCES
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LAB
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
19: Human Genome
INTRODUCTION
MAIN CONCLUSIONS OF HUMAN GENOME PROJECT
GATEWAYS TO ACCESS THE HUMAN GENOME
THE HUMAN GENOME PROJECT
24 HUMAN CHROMOSOMES
VARIATION: SEQUENCING INDIVIDUAL GENOMES
VARIATION: SNPS TO COPY NUMBER VARIANTS
PERSPECTIVE
PITFALLS
DISCUSSION QUESTIONS
PROBLEMS/COMPUTER LAB
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
20: Human Disease
HUMAN GENETIC DISEASE: A CONSEQUENCE OF DNA VARIATION
FOUR CATEGORIES OF DISEASE
DISEASE DATABASES
FOUR APPROACHES TO IDENTIFYING DISEASE-ASSOCIATED GENES
HUMAN DISEASE GENES IN MODEL ORGANISMS
FUNCTIONAL CLASSIFICATION OF DISEASE GENES
PERSPECTIVE
PITFALLS
WEB RESOURCES
DISCUSSION QUESTIONS
PROBLEMS
SELF-TEST QUIZ
SUGGESTED READING
REFERENCES
bioinformatics and functional genomics pdf
bioinformatics and functional genomics 4th edition
bioinformatics and functional genomics 3rd edition
facebook bioinformatics jobs
facebook bioinformatics
Tags: Jonathan Pevsner, Bioinformatics, Functional
4.5
17 reviews
5.0
41 reviews
4.8
6 reviews
4.6
23 reviews
4.4
39 reviews
4.6
16 reviews