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0 reviewsISBN 10: 0123749476
ISBN 13: 9780123749475
Author: Scott Brady
Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences.
The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology.
Neurons: structure and function
Macroglia and microglia
Blood-brain barrier and neurovascular unit
Cell membrane structure and function
Membrane transport: pumps, ion channels, active and passive transport
Electrical excitability and ion channels
Brain and neuronal lipids
Cytoskeleton (cell structural basis)
Intracellular transport and axonal transport
Cell adhesion molecules
Myelin structure and biochemistry
Brain energy metabolism
Synaptic transmission
Major neurotransmitters: acetylcholine, catecholamines, serotonin, histamine, glutamate, GABA, purinergic transmitters, peptides
G proteins and second messengers
Cyclic nucleotides (cAMP, cGMP)
Phosphoinositides
Calcium signaling
Serine/threonine and tyrosine phosphorylation
Transcription factors in the nervous system
Nervous system development (neurogenesis, gliogenesis, axon guidance, synaptogenesis)
Growth factors and stem cell roles
Myelin formation and maintenance
Axon growth and regeneration in adults
Molecular mechanisms of neuro-immune interactions
Neuroinflammation and microglial roles
Ischemia-reperfusion injury
Lipid mediators in neuroinflammation
Apoptosis and necrosis in neural injury
Peripheral neuropathies
Myelin disorders
Epilepsy
Common neurodegenerative diseases: Alzheimer’s, Parkinson’s, ALS, prion diseases, etc.
Amino acid metabolism, lysosomal, peroxisomal, mitochondrial disorders
Neuromuscular excitation disorders
Motor neuron diseases
Synuclein and tauopathies
Polyglutamine repeat disorders
Neurotransmitter disorders and basal ganglia diseases
Molecular basis of prion diseases
Vision: molecular basis and development
Olfaction and gustation
Audition and balance
Pain: mechanisms, transmission, and related factors
Endocrine influences on brain and behavior
Learning and memory
Neurochemistry of sleep and arousal
Neurochemistry of schizophrenia, autism
Neurochemistry of mood and anxiety disorders
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Tags: Scott Brady, Basic Neurochemistry