(Ebook) Bacterial cellular metabolic systems: Metabolic regulation of a cell system with 13C-metabolic flux analysis by Kazuyuki Shimizu ISBN 9781907568015, 1907568018

(Ebook) Bacterial cellular metabolic systems: Metabolic regulation of a cell system with 13C-metabolic flux analysis by Kazuyuki Shimizu ISBN 9781907568015, 1907568018

The metabolic regulation of a cell system is of critical importance in systems biology.  A robust model of these mechanisms is essential in predicting the effects on the metabolism of both the culture environment and the knockout of specific genes. The author focuses on this highly topical subject in relation to culture environment and provides a detailed analysis from gene level to metabolic level regulation, as well as offering a discussion of the most recent modelling approaches. Chapters introduce metabolic mechanisms and the metabolic regulation of a cell, discuss  the action of global regulators in response to a specific culture environment and examine conventional flux balance analysis and its applications, 13C-metabolic flux analysis, and the effect of a specific gene knockout on the metabolism.