(Ebook) Atopic Dermatitis: Inside Out or Outside in? by Lawrence S. Chan, Vivian Y. Shi ISBN 9780323847445, 0323847447, B09QX2VTZ9

(Ebook) Atopic Dermatitis: Inside Out or Outside in? by Lawrence S. Chan, Vivian Y. Shi ISBN 9780323847445, 0323847447, B09QX2VTZ9

Atopic dermatitis, a chronic, itchy, inflammatory skin disease,has caught the attention of the medical community in recentyears due to the disease’s significant increase in prevalenceover the last decades, particularly in the developed nations. Asa result, a substantial amount of investigations, in both clinicaland laboratory aspects, have been conducted in search foranswers of reasons underlying such increase of prevalence tooccur and for optimal therapeutic options. While many factorshave been viewed as contributors to the development ofthe disease, some seem to be on the opposite spectrum of theothers, no single root cause has been identified. On one hand,defect in certain skin barrier protein, like filaggrin, has beenfound in some patients affected by atopic dermatitis, pointingto external factors that penetrate the internal weakness of theskin to cause skin inflammation. On the other hand, explicitaltering of the skin immune milieu by artificially expressing aprominent Th2 cytokine interleukin-4 in the basal epidermisresults in the skin barrier-intact interleukin-4-transgenic micewith a disease phenotype that fulfills the clinical diagnosticcriteria of human atopic dermatitis, pointing to triggeringinternal factors of immune dysregulation.In Atopic Dermatitis: Inside Out or Outside In? we attemptto analyze this burdensome disease from a distinct perspective.The clinical and laboratory evidence in support ofinternally initiated factors and those in support of externallytriggered causes are delineated separately. We aim to developbetter understanding of the different components that mayinfluence the initiation, progression, and sustainment ofthis inflammatory disorder. The ultimate goal of this book isto help clinicians who care for atopic dermatitis to develop atherapeutic strategy consistent with the knowledge resultedfrom the most updated evidence.