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Available4.5
26 reviewsAtherosclerosis is a disease of large and medium arteries that can lead Introductionto life-threatening cardiovascular and cerebrovascular consequences, Emerging mechanisms and such as myocardial infarction and stroke. Moreover, atherosclerosis is therapeutic targetsa major contributor to cardiovascular-related mortality in individuals Current therapies and strategies in clinical with diabetes mellitus. Diabetes aggravates the pathobiological developmentmechanisms that underlie the development of atherosclerosis. Emerging therapeutic Currently available anti-atherosclerotic drugs or strategies solely strategiesfocus on optimal control of systemic risk factors, including Conclusionshyperglycaemia and dyslipidaemia, but do not adequately target the diabetes-exacerbated mechanisms of atherosclerotic cardiovascular disease, highlighting the need for targeted, mechanism-based therapies. This Review focuses on emerging pathological mechanisms and related novel therapeutic targets in atherosclerotic cardiovascular disease in patients with diabetes.
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