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14 reviewsSUMMARYComorbid anxiety symptoms are prominent affective components of chronic pain, yet the central mechanisms underlying these symptoms remain elusive. The central amygdala (CeA) regulates nociceptive processing and associated anxiety in chronic pain. However, the specific microcircuits and cell types withinthe CeA that regulate pain-related anxiety have not been fully elucidated. In this study, we discovered amicrocircuit in the CeA wherein dynorphinergic neurons of the lateral subdivision of the central amygdala(CeL) project to the medial subdivision (CeM), activation of which gates anxiogenic effects associated withchronic pain. Dynorphin-mediated activation of CeM astroglial kappa opioid receptors (KORs), dependentupon corticotropin-releasing factor (CRF) receptor 2 signaling, enhanced CeM neuron excitability bypromoting N-methyl-D-aspartate receptor (NMDAR) activation, likely via releasing gliotransmitter D-serine.Behaviorally, KOR-mediated bidirectional communication between CeA peptidergic neurons and astrocytesmodulates the anxiogenic effect of chronic pain. Our findings reveal a neuroglial microcircuit underlying painassociated anxiety and suggest potential targets for therapeutic intervention.