(Ebook) Antibody-Drug Conjugates by Ingrid Sassoon, Véronique Blanc (auth.), Laurent Ducry (eds.) ISBN 9781627035408, 9781627035415, 1627035400, 1627035419

(Ebook) Antibody-Drug Conjugates by Ingrid Sassoon, Véronique Blanc (auth.), Laurent Ducry (eds.) ISBN 9781627035408, 9781627035415, 1627035400, 1627035419

Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs. In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion. Written in the highly successful Methods in Molecular Biology™ format, these detailed chapters include the kind of practical implementation advice that guarantees quality results.