(Ebook) Animal Models of Human Disease Volume 100 1st Edition by Min Kyung Tai, Karen Chang ISBN 0123848784 9780123848789

Chapter 1: Modeling Human Prostate Cancer in Genetically Engineered Mice

I. Introduction

II. Technologies for Creating GEM Models

III. Prostate Tumor Models Driven by SV40 T Antigens

IV. Protooncogene-Driven Models

V. The Tumor Suppressor Models

VI. Androgen Signaling Disruption Models

VII. Models with Aberrant Cell Signaling

VIII. Remarks

References

Chapter 2: Modeling Cancers in Drosophila

I. Introduction

II. Drosophila and Cancer Cell Growth

III. Drosophila, Cancer and Tissue Growth

IV. Drosophila, Cancer, Differentiation, and Stemness

V. Drosophila, Cancer and Cell Polarity

VI. Drosophila and Metastasis

VII. Drosophila and Cancer Cell Environment

VIII. Drosophila and Specific Cancer Models

IX. Conclusion

Acknowledgments

References

Chapter 3: Probing Human Cardiovascular Congenital Disease Using Transgenic Mouse Models

I. Introduction

II. Congenital Heart Defects

III. Genetic Basis of Disease

IV. The Mouse as a Genetic Model

V. Transgenic Mice

VI. Gene Knockout and Gene Knockin Mice

VII. Conditional Knockout Mice

VIII. Inducible Mice

IX. Forward Genetic Approaches

X. Common CHDs

XI. Conclusion

Acknowledgments

References

Chapter 4: Dissection of Cardiovascular Development and Disease Pathways in Zebrafish

I. The Impact of Cardiovascular Disease and Need for Disease Models

II. Current Animal Models of Cardiovascular Disease

III. Molecular Tools to Study Zebrafish

IV. Approaches to Generate Zebrafish Models for Disease

V. Zebrafish as a Model System for the Study of Cardiovascular Disease

VI. Early Cardiovascular Development in Zebrafish is Similar to Humans

VII. Conserved Gene Programs, Cell Behavior, and Molecular Mechanisms

VIII. Zebrafish Cardiovascular Mutants as Disease Models

IX. Models for Studying Hemodynamic Forces and Valve Disease

X. Contribution of Blood Flow to Vessel Development

XI. Genes Associated with Cardiomyopathies Are Required for Contractile Function

XII. Gene Defects that Cause Arrhythmias

XIII. Shared Pathways in Zebrafish Development and Human Vascular Diseases

XIV. Molecules Required for Vessel Formation and Repair

XV. From Vascular Biology Research to AntiAngiogenic Therapy

XVI. Vessel Guidance in Development and Disease

XVII. Lymphangiogenesis and Lymphatic Vessel Dysfunction

XVIII. Models for Vascular Anomalies

XIX. New Directions for Cardiovascular Biology

XX. Summary

Acknowledgements/Grant Information

References

Chapter 5: Drosophila Models of Cardiac Disease

I. Introduction

II. Embryonic Cardiac Development

III. Cardiac Field

IV. Cardiomyocyte Differentiation

V. Migration/Adhesion

VI. Larval Heart Function

VII. Pacemaker Regulation

VIII. Adult Functional Models

IX. Single-Gene Disease Models

X. Disease Mechanisms

XI. Unbiased Screens-Disease Phenotypes

XII. Cardiac Aging

XIII. Diet and Exercise

XIV. Summary

References

Chapter 6: Animal Models of Retinal Disease

I. Introduction

II. Overview of Retinal Structure and Function

III. Genetics of Retinal Disease

IV. RP: A Family of Inherited Photoreceptor Degenerations

V. LCA: A Severe Retinal Degeneration Caused by Anomalies in RPE, Glial or Photoreceptor Dysfunction

VI. CSNB: An Opportunity to Better Understand Outer Retinal Signaling

VII. Inherited Macular Degenerations

VIII. Age-Related Macular Degeneration

IX. Animal Models of Retinal Vascular Diseases

X. Animal Models of Optic Nerve Disease

XI. Conclusions

Acknowledgments

References

Chapter 7: Toward a Better Understanding of Human Eye Disease: Insights From the Zebrafish, Danio re

I. Introduction

II. Posterior Segment

III. Anterior Segment

IV. Concluding Remarks

Acknowledgements

References

Chapter 8: 800 Facets of Retinal Degeneration

I. Retinal Diseases

II. Understanding the Developmental Process of Retinal Cell Types

III. Conserved Factors Involved in Eye Development

IV. Photoreceptor Structure Comparison

V. Factors Regulating Photoreceptor Morphogenesis and Maintenance

VI. Phototransduction and Disease

VII. Summary and Concluding Remarks

References

Chapter 9: Animal Models of Glycogen Storage Disorders

I. Introduction

II. Defects in Glycolysis

III. Defects in Glycogen Synthesis

IV. Defects in Glycogen Degradation

V. Unknown Mechanisms of Glycogen Accumulation

VI. Conclusion

References

Chapter 10: Modeling Disorders of Fatty Acid Metabolism in the Mouse

I. Introduction to Fatty Acid Oxidation

II. Overview of the Mitochondrial Pathway

III. Genetic Models of Fatty Acid Oxidation Disorders

IV. Nongenetic Models of Fatty Acid Oxidation Disorders

V. Legacy of Mouse Models and Future Directions

References

Chapter 11: Genetic Mouse Models of Neurodegenerative Diseases

I. Introduction

II. Parkinson's Disease

III. Mouse Models of Alzheimer's Disease

IV. Mouse Models for HD

V. Mouse Models for ALS

VI. Conclusions

Acknowledgments

References

Chapter 12: Demise of the Flies: Why Drosophila Models Still Matter

I. The Making of a Fly Model

II. Alzheimer Disease

III. Parkinson's Disease

IV. Polyglutamine Disease

V. Amyotrophic Lateral Sclerosis

VI. Concluding Remarks

References

Chapter 13: Watching Worms Whither: Modeling Neurodegeneration in C. elegans

I. Introduction

II. Modeling the Pathophysiology of AD: beta-Amyloid, Tau, and Presenilin

III. Modeling Dopaminergic Dysfunction

IV. Models of Parkinson's Disease: Neurotoxins, α-Synuclein, and LRRK2

V. Models of Axonal Degeneration: Laser Ablation

VI. Conclusion

Acknowledgments

References