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0 reviewsSUMMARYChronic pain affects a substantial portion of the population, yet current treatments often fail to provideadequate relief. Non-pharmacological interventions, which target behaviors and brain processes underlyingthe experience of pain, hold promises in offering relief for people with chronic pain. This review consolidatesthe current knowledge concerning the efficacy of non-pharmacological interventions for chronic pain. Wefocus on psychological interventions (e.g., cognitive behavioral therapy-based interventions and emotionbased therapies) that use mental techniques and physical practices (e.g., exercise, massage, acupuncture,and yoga) that use body techniques to reduce pain. The efficacy of neuromodulation is also discussed. Giventhat placebo and expectation effects may enhance benefits for non-pharmacological interventions, we alsodiscuss placebo interventions and expectation management practices. Finally, we describe digital therapeutics as an emerging approach for managing chronic pain. We argue that non-pharmacological interventionsare critical adjunctive or stand-alone interventions for chronic pain conditions.