(Ebook) Alzheimer's Disease by Philippe Derreumaux (ed.) ISBN 9781848167544, 1848167547

(Ebook) Alzheimer's Disease by Philippe Derreumaux (ed.) ISBN 9781848167544, 1848167547

A large body of evidence points, however, to the early A -formed oligomers as the primary toxic species in Alzheimer's disease. A powerful strategy for developing pharmaceutical treatments against Alzheimer's is to elucidate the pathways of oligomer formation and determine the structures of the toxic aggregates.

This book provides a panoramic view across recent in vitro and in vivo studies along with state-of-the-art computer simulations, designed to increase the readers' understanding of A oligomerisation and fibril formation. At the same time, the book delves into the pathogenesis of familial and sporadic Alzheimer's disease at the atomic level of detail.

Written by leading authors in their respective fields, this book will be valuable to all scientists working on Alzheimer's disease.

Readership: General public, PhD students, postdocs, as well as all scientists working in the following fields: Alzheimer's disease, amyloids, neuroscience, oligomers, protofibrils, fibrils, toxicity, structures, dynamics, kinetics, thermodynamics, all-atom and coarse grained simulations, biophysics, memory, learning, transgenic mouse models, metal ions, membrane, nanoparticles, computational chemistry, drug design and bioinformatics.