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ISBN 13: 9780120176564
Author: Jeffrey C Hall, Jay C Dunlap, Theodore Friedmann and Veronica van Heyningen
The field of genetics is rapidly evolving and new medical breakthroughs are occurring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Articles covered in this volume include Biological Activity and Biotechnological Aspects of Peptide Nucleic Acid (PNA); Changing Images of the Gene; Historical and Modern Genetics of Plant Graft Hybridization; Step into the Groove: Engineered Transcription Factors as Modulators of Gene Expression; Step Out of the Groove: Epigenetic Gene Control Systems and Engineered Transcription Factors.
Chapter 1: Biological Activity and Biotechnological Aspects of Peptide Nucleic Acid
I. Introduction
II. PNA: Chemistry and Structure
III. Biological Activity
IV. Biotechnological Aspects of PNA
V. Concluding Remarks
Acknowledgments
References
Chapter 2: Changing Images of the Gene
I. Introduction
II. The Hypothetical Gene
III. Physical Concepts of the Gene
IV. Chemical Nature of the Gene
V. The Genetic Code
VI. Structure of the Gene
VII. Molecular Units of the Gene
VIII. Higher Orders of Genes
IX. Gene Number and Gene Size
X. Genes in the Cytoplasm
XI. Epigenetics
XII. Prions
XIII. Conclusions and Outlook
XIV. Epilog
Acknowledgments
References
Chapter 3: Historical and Modern Genetics of Plant Graft Hybridization
I. Introduction
II. Historical Background
III. The Existence of Graft Hybrids
IV. Methods of Graft Hybridization
V. Characteristics of Graft Hybridization
VI. Mechanisms Underlying Graft Hybridization
VII. Significance of Graft Hybridization
VIII. Conclusions
Acknowledgments
References
Chapter 4: Step into the Groove: Engineered Transcription Factors as Modulators of Gene Expression
I. Introduction
II. Transcriptional Therapy
III. Engineered Zinc-Finger-Based Transcription Factors (ZF-TFs) and the Influence of Nucleosomes
IV. Concluding Remarks and Future Perspectives
Acknowledgments
References
Chapter 5: Step out of the Groove: Epigenetic Gene Control Systems and Engineered Transcription Fact
I. Influence of Epigenetic Mechanisms on Gene Expression
II. How Do ZF-TFs Modulate Epigenetic Gene Regulation?
III. Epigenetic Aspects to Consider for ZF-TF Approaches
Acknowledgments
References
Index
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Tags: Jeffrey C Hall, Jay C Dunlap, Theodore Friedmann and Veronica van Heyningen, Genetics
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