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A wireless optogenetic stimulation system for long-term function evaluation of mice forelimb with sub-nerve resolution by Mingjie Zhou & Biao Yan & Fukui Yang & Chuxiang Chen & Fei Wang & Chenpei Xu & Tingzheng Jiang & Kexin Li & Yuanting Xie & Hao Zheng & Chengyang Wang & Jiayi Zhang & Su Jiang instant download

  • SKU: EBN-239352868
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Instant download (eBook) A wireless optogenetic stimulation system for long-term function evaluation of mice forelimb with sub-nerve resolution after payment.
Authors:Mingjie Zhou & Biao Yan & Fukui Yang & Chuxiang Chen & Fei Wang & Chenpei Xu & Tingzheng Jiang & Kexin Li & Yuanting Xie & Hao Zheng & Chengyang Wang & Jiayi Zhang & Su Jiang
Pages:updating ...
Year:2025
Publisher:x
Language:english
File Size:6.61 MB
Format:pdf
Categories: Ebooks

Product desciption

A wireless optogenetic stimulation system for long-term function evaluation of mice forelimb with sub-nerve resolution by Mingjie Zhou & Biao Yan & Fukui Yang & Chuxiang Chen & Fei Wang & Chenpei Xu & Tingzheng Jiang & Kexin Li & Yuanting Xie & Hao Zheng & Chengyang Wang & Jiayi Zhang & Su Jiang instant download

Nature Communications, doi:10.1038/s41467-025-63746-y

Peripheral nerve transfer is an effective surgical method in restoring motorfunctions of upper limb after peripheral nerve injuries. However, the outcomeof individual function recovery is less predictable. It is crucial to access thelong-term evaluation of function improvement. Here, we developed a fullyimplantable multisite optogenetic stimulation system, which is tailored forwireless, reprogrammable and long-term function evaluation of peripheralnerve plexus with sub nerve resolution. In Thy1-ChR2-EYFP mice, our systeminduced distinct compound muscle action potentials and forelimb movementswhen illuminating different nerve fascicles. Furthermore, we applied the system on a nerve transfer mice model after traumatic brain injury and discoveredinnervation pattern of the transferred and adjacent nerves to multiple musclesconsecutively within 12 weeks after surgery. Our system enabled refined evaluation of electrophysiological and motor functions of peripheral nerveplexus, shining light upon personalized diagnosis and treatment after nerveinjuries or surgeries.

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