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24 reviewsUnpleasant sounds elicit a range of negative emotional reactions, yet the1234567890():,;1234567890():,;underlying neural mechanisms remain largely unknown. Here we show thatglutamatergic neurons in the central inferior colliculus (CICglu) relay noiseinformation to GABAergic neurons in the ventral tegmental area (VTAGABA) viathe cuneiform nucleus (CnF), encoding negative emotions in mice. In contrast,the CICglu→medial geniculate (MG) canonical auditory pathway processessalient stimuli. By combining viral tracing, calcium imaging, and optroderecording, we demonstrate that the CnF acts downstream of CICglu to conveynegative valence to the mesolimbic dopamine system by activating VTAGABAneurons. Optogenetic or chemogenetic inhibition of any connection withinthe CICglu→CnFglu → VTAGABA circuit, or direct excitation of the mesolimbicdopamine (DA) system is sufficient to alleviate noise-induced negativeemotion perception. Our findings highlight the significance of theCICglu→CnFglu → VTAGABA circuit in coping with acoustic stressors.
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