(Ebook) A Guide to Practical Toxicology Evaluation Prediction and Risk 2nd Edition by Woolley Adam ISBN 1420043145 9781420043143

(Ebook) A Guide to Practical Toxicology Evaluation Prediction and Risk 2nd Edition by Woolley Adam ISBN 1420043145 9781420043143

(Ebook) A Guide to Practical Toxicology Evaluation Prediction and Risk 2nd Edition by Woolley Adam - Ebook PDF Instant Download/Delivery: 1420043145, 9781420043143
Full download (Ebook) A Guide to Practical Toxicology Evaluation Prediction and Risk 2nd Edition after payment

Product details:

ISBN 10: 1420043145 
ISBN 13: 9781420043143
Author: Woolley Adam

This practical, user-friendly, and informative text surveys basic principles of toxicology. It is an invaluable guide to evaluating toxicity and related data, approaching toxicity testing and interpretation, and understanding the concepts of hazard prediction and risk assessment and management.

A Guide to Practical Toxicology:

• examines how to evaluate various groups of chemicals―pharmaceuticals, cosmetics, and agrochemicals
• provides insights on toxicity determination, normality and naturality, prediction, and regulation

Two all-new chapters cover:

• safety pharmacology
• evaluation of different chemical classes

(Ebook) A Guide to Practical Toxicology Evaluation Prediction and Risk 2nd Table of contents:

• Part I: Basic Principles and Tools of Toxicology

  • Chapter 1: Introduction to Practical Toxicology and Risk Assessment

    • Defining Toxicology and Its Scope

    • The Evolution of Toxicology

    • Risk Assessment Framework

    • Role of the Toxicologist

  • Chapter 2: Dose-Response Relationships

    • Fundamentals of Dose-Response

    • Types of Dose-Response Curves (Graded, Quantal)

    • LD50, EC50, NOAEL, LOAEL

    • Factors Influencing Dose-Response

  • Chapter 3: Absorption, Distribution, Metabolism, and Excretion (ADME)

    • Routes of Exposure

    • Mechanisms of Absorption

    • Distribution of Toxicants

    • Biotransformation (Metabolism)

    • Excretion Pathways

    • Pharmacokinetics and Toxicokinetics

  • Chapter 4: Target Organ Toxicity and Mechanisms of Action

    • General Mechanisms of Toxicity (e.g., DNA damage, oxidative stress)

    • Toxicity to Specific Organs (e.g., Liver, Kidney, Nervous System)

    • Cellular and Molecular Basis of Toxicity

  • Chapter 5: Chemical Structure and Toxicity

    • Structure-Activity Relationships (SAR)

    • Quantitative Structure-Activity Relationships (QSAR)

    • Using Chemical Properties for Toxicity Prediction

• Part II: Toxicological Evaluation and Testing

  • Chapter 6: Acute Toxicity Testing

    • Purpose and Methods

    • Animal Models

    • Interpreting Acute Toxicity Data

    • Alternative Methods

  • Chapter 7: Subchronic and Chronic Toxicity Testing

    • Design of Repeated-Dose Studies

    • Endpoints and Data Analysis

    • Extrapolation to Humans

  • Chapter 8: Developmental and Reproductive Toxicology

    • Principles of Developmental Toxicity

    • Teratogenicity Testing

    • Reproductive Toxicity Assessment

  • Chapter 9: Mutagenicity and Carcinogenicity Testing

    • Mechanisms of Mutagenesis and Carcinogenesis

    • In Vitro and In Vivo Assays for Mutagenicity

    • Long-Term Carcinogenicity Studies

  • Chapter 10: Neurotoxicity Testing

    • Assessment of Nervous System Toxicity

    • Behavioral and Electrophysiological Endpoints

  • Chapter 11: Immunotoxicity Testing

    • Effects of Chemicals on the Immune System

    • Immunotoxicity Assays

  • Chapter 12: In Vitro and Alternative Methods in Toxicology

    • Cell Culture Models

    • High-Throughput Screening

    • Computational Toxicology (In Silico Methods)

• Part III: Risk Assessment, Prediction, and Management

  • Chapter 13: Hazard Identification

    • Sources of Toxicological Information

    • Weight of Evidence Approach

  • Chapter 14: Dose-Response Assessment

    • Reference Doses (RfD) and Reference Concentrations (RfC)

    • Cancer Potency Factors

  • Chapter 15: Exposure Assessment

    • Quantifying Exposure (Routes, Pathways, Doses)

    • Modeling Exposure

    • Biomonitoring

  • Chapter 16: Risk Characterization

    • Integrating Hazard, Dose-Response, and Exposure

    • Uncertainty Factors and Variability

    • Probabilistic Risk Assessment

  • Chapter 17: Ecological Risk Assessment

    • Principles and Framework

    • Assessment of Environmental Contaminants

  • Chapter 18: Biomarkers in Toxicology and Risk Assessment

    • Types of Biomarkers

    • Applications in Exposure, Effect, and Susceptibility

  • Chapter 19: Regulatory Toxicology and Risk Management

    • Toxicology in Regulatory Decision-Making

    • Major Environmental Regulations (e.g., Clean Air Act, Clean Water Act, TSCA)

    • Global Regulatory Frameworks

  • Chapter 20: Emerging Issues in Toxicology

    • Nanomaterials Toxicology

    • Endocrine Disruptors

    • Mixture Toxicity

    • Personalized Toxicology

People also search for (Ebook) A Guide to Practical Toxicology Evaluation Prediction and Risk 2nd:

toxicology books for beginners
    
toxicology in a box pdf free download
    
a practical guide to texas evidence
    
a guide to biology lab rust pdf
    
u of a toxicology

Tags: Woolley Adam, Practical, Toxicology